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Blmhtm1Geh
Targeted Allele Detail
Nomenclature
Symbol: Blmhtm1Geh
Name: bleomycin hydrolase; targeted mutation 1, Gregg E Homanics
MGI ID: MGI:1861798
Synonyms: Bh-, Blmhtm2Geh
Gene: Blmh  Location: Chr11:76924809-76987379 bp, + strand  Genetic Position: Chr11, 46.16 cM
Gross appearance and histopathology of tail dermatitis on Blmhtm1Geh/Blmhtm1Geh mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:54585
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA genomic fragment containing exon 3 and flanking DNA was replaced with a neomycin selection cassette. The deleted sequences include the region encoding the catalytic cysteine of the protein. Northern blot analysis on total embryonic RNA derived from homozygous mice demonstrated that no transcript was produced from this allele. Western blot and enzymatic activity assays confirmed that no functional protein was made in homozygous mice. (J:54585)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Blmh Mutation:  10 strains or lines available
References
Original:  J:54585 Schwartz DR, et al., The neutral cysteine protease bleomycin hydrolase is essential for epidermal integrity and bleomycin resistance. Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4680-5
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory