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Targeted Allele Detail
Symbol: Agatm1Vk
Name: aspartylglucosaminidase; targeted mutation 1, Vesa Kaartinen
MGI ID: MGI:1861793
Synonyms: Aga-, AGU
Gene: Aga  Location: Chr8:53511702-53523421 bp, + strand  Genetic Position: Chr8, 29.13 cM, cytoband B3
Germline Transmission:  Earliest citation of germline transmission: J:37022
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neomycin selection cassette was inserted into the coding sequences in exon 3. Northern blot analysis and RT-PCR demonstrated that no detectable transcript is produced from this allele. Enzyme activity assays on liver and brain extracts of homozygous mice confirmed that no functional protein is made from this allele. (J:37022)
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Aga Mutation:  2 strains or lines available
Original:  J:37022 Kaartinen V, et al., A mouse model for the human lysosomal disease aspartylglycosaminuria. Nat Med. 1996 Dec;2(12):1375-8
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
The Jackson Laboratory