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Acvr2atm1Zuk
Targeted Allele Detail
Nomenclature
Symbol: Acvr2atm1Zuk
Name: activin receptor IIA; targeted mutation 1, Martin M Matzuk
MGI ID: MGI:1861779
Synonyms: actRcIIm1, Acvr2-
Gene: Acvr2a  Location: Chr2:48814109-48903264 bp, + strand  Genetic Position: Chr2, 28.38 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:23924
Parent Cell Line:  AB2.1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA PGK-hprt minigene replaced a genomic fragment containing the initiation codon and the sequences encoding the signal peptide. Northern blot analysis indicated that no transcript was detectable in liver of homozygous mice. (J:23924)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 13 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Acvr2a Mutation:  27 strains or lines available
References
Original:  J:23924 Matzuk MM, et al., Different phenotypes for mice deficient in either activins or activin receptor type II [see comments]. Nature. 1995 Mar 23;374(6520):356-60
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory