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Wastm1Sbs
Targeted Allele Detail
Nomenclature
Symbol: Wastm1Sbs
Name: Wiskott-Aldrich syndrome; targeted mutation 1, Scott B Snapper
MGI ID: MGI:1861707
Synonyms: Was-, wasp-
Gene: Was  Location: ChrX:8081453-8090498 bp, - strand  Genetic Position: ChrX, 3.65 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:48836
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin cassette was inserted into exon 7, which encodes part of the GTPase-binding domain. The absence of transcript and protein produced from the targeted allele in male hemizygous mutant mice was confirmed by Northern blot and Western blot analyses. (J:48836)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 10 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Was Mutation:  4 strains or lines available
References
Original:  J:48836 Snapper SB, et al., Wiskott-Aldrich syndrome protein-deficient mice reveal a role for WASP in T but not B cell activation. Immunity. 1998 Jul;9(1):81-91
All:  66 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/10/2018
MGI 6.12
The Jackson Laboratory