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Targeted Allele Detail
Symbol: Itgb2tm2Bay
Name: integrin beta 2; targeted mutation 2, Baylor College of Medicine
MGI ID: MGI:1861705
Synonyms: beta2-, CD18-, CD18 null, Itgb2-
Gene: Itgb2  Location: Chr10:77530252-77565708 bp, + strand  Genetic Position: Chr10, 39.72 cM
Skeletal abnormalities in Itgb2tm2Bay/Itgb2tm2Bay mice

Show the 3 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:13599
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neomycin cassette disrupted the 5' boundary of exon 3. No protein was synthesized from this allele. (J:48542)
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Itgb2 Mutation:  9 strains or lines available
Trans heterozgous mice (Itgb2tm1Bay / Itgb2tm2Bay) on a mixed background that includes the strain PL/J and trans heterozygous mice on a congenic PL/J background display Phenotypic Similarity to Human Syndrome: Psoriasis. However, mice on backgrounds that do not include PL/J do not display psoriasis. (J:32126, J:84126)

Original:  J:13599 Wilson RW, et al., Gene targeting yields a CD18-mutant mouse for study of inflammation. J Immunol. 1993 Aug 1;151(3):1571-8
All:  95 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.0
The Jackson Laboratory