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Targeted Allele Detail
Symbol: Itgb2tm2Bay
Name: integrin beta 2; targeted mutation 2, Baylor College of Medicine
MGI ID: MGI:1861705
Synonyms: beta2-, CD18-, CD18 null, Itgb2-
Gene: Itgb2  Location: Chr10:77530252-77565708 bp, + strand  Genetic Position: Chr10, 39.72 cM
Skeletal abnormalities in Itgb2tm2Bay/Itgb2tm2Bay mice

Show the 3 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:13599
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neomycin cassette disrupted the 5' boundary of exon 3. No protein was synthesized from this allele. (J:48542)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Itgb2 Mutation:  28 strains or lines available
Trans heterozgous mice (Itgb2tm1Bay / Itgb2tm2Bay) on a mixed background that includes the strain PL/J and trans heterozygous mice on a congenic PL/J background display Phenotypic Similarity to Human Syndrome: Psoriasis. However, mice on backgrounds that do not include PL/J do not display psoriasis. (J:32126, J:84126)
Original:  J:13599 Wilson RW, et al., Gene targeting yields a CD18-mutant mouse for study of inflammation. J Immunol. 1993 Aug 1;151(3):1571-8
All:  99 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.10
The Jackson Laboratory