Htt^tm3Mem
Targeted Allele Detail

Summary

• Symbol: Htt^tm3Mem
• Name: huntingtin; targeted mutation 3, Marcy E MacDonald
• MGI ID: MGI:1861699
• Synonyms: Hdh^Q50
• Gene: Htt Location: Chr5:34919084-35069878 bp, + strand Genetic Position: Chr5, 17.92 cM
• Alliance: Htt^tm3Mem page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:44391
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutation: Insertion
• Mutation details: This allele carries 48 CAG repeat units, with 50 glutamines, in the first exon of the endogenous gene. It is a derivative from Hdh^tm7Mem in which the neo cassette has been removed by cre-mediated recombination and expresses normal levels of the mutant protein. (J:44391)

Disease models

Expression

In Mice Carrying this Mutation:

8 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Htt Mutation: 179 strains or lines available

References

• Original: J:44391 White JK, et al., Huntingtin is required for neurogenesis and is not impaired by the Huntington's disease CAG expansion. Nat Genet. 1997 Dec;17(4):404-10
• All: 13 reference(s)