Cdh11^tm1Mta
Targeted Allele Detail

Summary

• Symbol: Cdh11^tm1Mta
• Name: cadherin 11; targeted mutation 1, Masatoshi Takeichi
• MGI ID: MGI:1861184
• Synonyms: cad11(-)
• Gene: Cdh11 Location: Chr8:103358727-103512125 bp, - strand Genetic Position: Chr8, 50.44 cM
• Alliance: Cdh11^tm1Mta page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:58409
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Most of exon 16, encoding the last 56 amino acids of the extracellular domain and most of the transmembrane domain, was replaced with a neomycin cassette. A 97 kD truncated protein is expressed from this allele; authors state that this is a non-functional protein, and furthermore does not have any dominant negative effects. (J:58409)

Expression

In Mice Carrying this Mutation:

27 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cdh11 Mutation: 42 strains or lines available

References

• Original: J:58409 Horikawa K, et al., Adhesive subdivisions intrinsic to the epithelial somites. Dev Biol. 1999 Nov 15;215(2):182-9
• All: 22 reference(s)