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Cdh2tm1Hyn
Targeted Allele Detail
Nomenclature
Symbol: Cdh2tm1Hyn
Name: cadherin 2; targeted mutation 1, Richard Hynes
MGI ID: MGI:1861181
Synonyms: Cdh2-, N-cadherin-
Gene: Cdh2  Location: Chr18:16588877-16809246 bp, - strand  Genetic Position: Chr18, 10.1 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:37888
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin cassette was inserted into the exon 10, which encodes part of the extracellular domain of the protein. The protein was untectectable in Western blots of protein lysates derived from homozygous mutant embryos. (J:37888)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 53 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cdh2 Mutation:  5 strains or lines available
References
Original:  J:37888 Radice GL, et al., Developmental defects in mouse embryos lacking N-cadherin. Dev Biol. 1997 Jan 1;181(1):64-78
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/25/2015
MGI 5.21
The Jackson Laboratory