Dync1h1^Swl
Radiation induced Allele Detail

Summary

• Symbol: Dync1h1^Swl
• Name: dynein cytoplasmic 1 heavy chain 1; sprawling
• MGI ID: MGI:1861136
• Synonyms: Swl
• Gene: Dync1h1 Location: Chr12:110567886-110633379 bp, + strand Genetic Position: Chr12, 60.7 cM
• Alliance: Dync1h1^Swl page

Mutation origin

• Strain of Origin: (C3H/HeH x 101/H)F1

Mutation description

• Allele Type: Radiation induced
• Mutation: Intragenic deletion
• Mutation details: The molecular mutation is a 9-bp deletion in exon 12 of the gene, that affects residues 1040-1043 in the encoded protein. This mutation results in the change of four amino acids [glycine (GGC), isoleucine (ATA), valine (GTG), and threonine (ACT)] to an alanine (GCT) in the cargo-binding domain of the mature protein. RT-PCR analysis indicates that mRNA expression of this allele is not altered in mutant mice, and immunohistochemistry experiments in mutant embryos shows that no gross differences in the level or localization of the encoded protein is evident. (J:131126)
• Inheritance: Semidominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Dync1h1 Mutation: 194 strains or lines available

References

• Original: J:13469 Morris T, Sprawling (Swl). Mouse News Lett. 1967;37:29
• All: 9 reference(s)