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Dync1h1Swl
Radiation induced Allele Detail
Nomenclature
Symbol: Dync1h1Swl
Name: dynein cytoplasmic 1 heavy chain 1; sprawling
MGI ID: MGI:1861136
Synonyms: Swl
Gene: Dync1h1  Location: Chr12:110567886-110633379 bp, + strand  Genetic Position: Chr12, 60.7 cM
Mutation
origin
Strain of Origin:  (C3H/HeH x 101/H)F1
Mutation
description
Allele Type:    Radiation induced
Mutation:    Intragenic deletion
 
Mutation detailsThe molecular mutation is a 9-bp deletion in exon 12 of the gene, that affects residues 1040-1043 in the encoded protein. This mutation results in the change of four amino acids [glycine (GGC), isoleucine (ATA), valine (GTG), and threonine (ACT)] to an alanine (GCT) in the cargo-binding domain of the mature protein. RT-PCR analysis indicates that mRNA expression of this allele is not altered in mutant mice, and immunohistochemistry experiments in mutant embryos shows that no gross differences in the level or localization of the encoded protein is evident. (J:131126)
Inheritance:    Semidominant
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Dync1h1 Mutation:  131 strains or lines available
References
Original:  J:13469 Morris T, Sprawling (Swl). Mouse News Lett. 1967;37:29
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/16/2021
MGI 6.17
The Jackson Laboratory