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Cfbtm1Hrc
Targeted Allele Detail
Nomenclature
Symbol: Cfbtm1Hrc
Name: complement factor B; targeted mutation 1, Harvey R Colten
MGI ID: MGI:1861129
Synonyms: Bf-, Cfb-, Factor B-, fB-
Gene: Cfb  Location: Chr17:35075350-35081492 bp, - strand  Genetic Position: Chr17, 18.41 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:42679
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129S/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced exons 3 through 7 of the gene. Northern blots of liver from homozygous mutant mice showed no detectable full-length transcript, but did show a smaller, truncated transcript when probes encompassing segments 5' or 3' to the deleted segment were used. Small amounts of truncated, but not intact, protein were detected in peritoneal macrophages from homozygous mutant mice. However, sera from homozygous mutant mice showed no detectable protein activity. (J:42679)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 2 assay results
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cfb Mutation:  20 strains or lines available
Notes
ES cell line = D3 (129S2/SvPas) or J1 (129S4/SvJae).
References
Original:  J:42679 Matsumoto M, et al., Abrogation of the alternative complement pathway by targeted deletion of murine factor B. Proc Natl Acad Sci U S A. 1997 Aug 5;94(16):8720-5
All:  71 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/05/2021
MGI 6.17
The Jackson Laboratory