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Cfbtm1Hrc
Targeted Allele Detail
Nomenclature
Symbol: Cfbtm1Hrc
Name: complement factor B; targeted mutation 1, Harvey R Colten
MGI ID: MGI:1861129
Synonyms: Bf-, Cfb-, Factor B-, fB-
Gene: Cfb  Location: Chr17:34856374-34862518 bp, - strand  Genetic Position: Chr17, 18.41 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:42679
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129S/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced exons 3 through 7 of the gene. Northern blots of liver from homozygous mutant mice showed no detectable full-length transcript, but did show a smaller, truncated transcript when probes encompassing segments 5' or 3' to the deleted segment were used. Small amounts of truncated, but not intact, protein were detected in peritoneal macrophages from homozygous mutant mice. However, sera from homozygous mutant mice showed no detectable protein activity. (J:42679)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 2 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cfb Mutation:  9 strains or lines available
Notes
ES cell line = D3 (129S2/SvPas) or J1 (129S4/SvJae).
References
Original:  J:42679 Matsumoto M, et al., Abrogation of the alternative complement pathway by targeted deletion of murine factor B. Proc Natl Acad Sci U S A. 1997 Aug 5;94(16):8720-5
All:  63 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory