Med1^tm1Rgr
Targeted Allele Detail

Summary

• Symbol: Med1^tm1Rgr
• Name: mediator complex subunit 1; targeted mutation 1, Robert G Roeder
• MGI ID: MGI:1861125
• Synonyms: Trap220^-
• Gene: Med1 Location: Chr11:98042980-98084119 bp, - strand Genetic Position: Chr11, 61.75 cM, cytoband D
• Alliance: Med1^tm1Rgr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:61840
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lacZ-PGK-neo cassette was inserted via homologous recombination resulting in deletion of most of the gene product, including loss of all LXXLL motifs and nuclear receptor coactivator function. Reporter gene assays showed expression was greatly reduced in mouse embyonic fibroblasts cultured from homozygous mutant embyros. (J:61840)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

14 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Med1 Mutation: 83 strains or lines available

References

• Original: J:61840 Ito M, et al., Involvement of the TRAP220 component of the TRAP/SMCC coactivator complex in embryonic development and thyroid hormone action. Mol Cell. 2000 Apr;5(4):683-93
• All: 7 reference(s)