Med1tm1Jkr
Targeted Allele Detail
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Symbol: |
Med1tm1Jkr |
Name: |
mediator complex subunit 1; targeted mutation 1, Janardan K Reddy |
MGI ID: |
MGI:1861123 |
Synonyms: |
PBP- |
Gene: |
Med1 Location: Chr11:98042980-98084119 bp, - strand Genetic Position: Chr11, 61.75 cM, cytoband D
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Alliance: |
Med1tm1Jkr page
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Histological and ultrastructural alterations in Med1tm1Jkr/Med1tm1Jkr placenta
Show the 5 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:62272
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Parent Cell Line: |
HM-1 (ES Cell)
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Strain of Origin: |
129P2/OlaHsd-Hprt1b-m3
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Allele Type: |
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Targeted (Null/knockout) |
Mutation: |
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Insertion
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Mutation details: Exons 12-14 were disrupted with a PGK-neo cassette via homologous recombination resulting in the loss of 2 LXXLL motifs. Northern and Western blot analysis of fibroblasts from homozygous mutant embryos showed absence of gene transcript and protein product.
(J:62272)
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Inheritance: |
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Recessive |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Med1 Mutation: |
83 strains or lines available
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Original: |
J:62272 Zhu Y, et al., Deletion of PBP/PPARBP, the gene for nuclear receptor coactivator peroxisome proliferator-activated receptor-binding protein, results in embryonic lethality. J Biol Chem. 2000 May 19;275(20):14779-82 |
All: |
2 reference(s) |
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