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Transgenic Allele Detail
Symbol: Hfm
Name: hemifacial microsomia-associated locus
MGI ID: MGI:1861103
Synonyms: 643-7, microtia, Tg(MBP)643Mok
Gene: Hfm  Location: unknown  Genetic Position: Chr10, cytoband B1-3
Strain of Origin:  SWV-Mbpshi
Transgene Type:    Transgenic
Mutations:    Deletion, Insertion
  Hfm involves 1 genes/genome features (Hfm) View all
Mutation detailsA 23 Kb deletion on chromosome 10 occurred at the integration site of a transgene that expressed myelin basic protein. (J:21097)
Inheritance:    Dominant
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hfm Mutation:  0 strains or lines available
This mutation was generated by by pronuclear injection of a transgene into SWV-Mbpshi fertilized oocytes. Approximately 50-100 copies initially inserted into this locus, but the copy number decreased to 1 or a few during the course of breeding. This decrease of copy number had no effect on the phenotype. Some mice were mated to a B6C female to expand to an F3 generation.

Original:  J:77548 Kimura M, et al., Restoration of myelin formation by a single type of myelin basic protein in transgenic shiverer mice. Proc Natl Acad Sci U S A. 1989 Jul;86(14):5661-5
All:  3 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.03
The Jackson Laboratory