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Tnfrsf1atm1Blt
Targeted Allele Detail
Nomenclature
Symbol: Tnfrsf1atm1Blt
Name: tumor necrosis factor receptor superfamily, member 1a; targeted mutation 1, Horst Bluethmann
MGI ID: MGI:1861040
Synonyms: p55-, p55TNFR-, R1KO, Rothe Tnfrsf1a-, Tnfr10, TnfRI-, TNFRp55
Gene: Tnfrsf1a  Location: Chr6:125349362-125362484 bp, + strand  Genetic Position: Chr6, 59.32 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:14424
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details
Inheritance:    Recessive
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Tnfrsf1a Mutation:  15 strains or lines available
Notes
Mice homozygous for this allele lack the type 1 receptor (J:14424). Mouse embryos produce TNF and its receptors (J:16646), and the evidence suggests that TNF is involved in important physiological functions. However, homozygous mutant mice develop normally and are fertile with normal litter sizes (J:21202). These mice resist toxicity of low dosage lipopolysaccharide treatment, mediated by the type 1 receptor, although they remain sensitive to high lipopolysaccharide doses. They are also more sensitive to infection with Listeria monocytogenes (J:14424). Cytotoxic T lymphocyte induction by TNF via Tnfrsf1a is not essential to the response to viral infection, homozygous mutant mice being capable of controlling viral infection normally. It is, of course, possible that the essential receptor molecule in these reactions is TNFRSF1B, or that TNFRSF1B can substitute for TNFRSF1A in the absence of the latter (J:21202). A differential response of mutant homozygotes to activation by mouse TNF, which can activate either TNFRSF1A or TNFRSF1B, and human TNF, which is selectively interactive with TNFRSF1A only, suggests that substitution can take place in some circumstances (J:21648). On the other hand, TNF inhibition of Csh2 expression is mediated through the TNFRSF1A, but not the TNFRSF1B, receptor (J:19617).

References
Original:  J:14424 Rothe J, et al., Mice lacking the tumour necrosis factor receptor 1 are resistant to TNF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes. Nature. 1993 Aug 26;364(6440):798-802
All:  113 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory