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Tnftm1Jods
Targeted Allele Detail
Nomenclature
Symbol: Tnftm1Jods
Name: tumor necrosis factor; targeted mutation 1, Johnathon D Sedgwick
MGI ID: MGI:1860953
Synonyms: TNF-, TNF -, TNFalpha-, TNF-KO
Gene: Tnf  Location: Chr17:35199381-35202007 bp, - strand  Genetic Position: Chr17, 18.59 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:43602
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details905 base pairs, encompassing exons 2, 3, and a portion of exon 4, were replaced with a neomycin selection cassette. RT-PCR confirmed the absence of transcript in homozygous mutant mice. (J:43602)
Inheritance:    Not Specified
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tnf Mutation:  28 strains or lines available
Notes
ES cell lines = BL/6-III and Bruce 4
References
Original:  J:43602 Korner H, et al., Distinct roles for lymphotoxin-alpha and tumor necrosis factor in organogenesis and spatial organization of lymphoid tissue. Eur J Immunol. 1997 Oct;27(10):2600-9
All:  73 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory