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Tlr4lps-del
Spontaneous Allele Detail
Summary
Symbol: Tlr4lps-del
Name: toll-like receptor 4; defective lipopolysaccharide response, deletion
MGI ID: MGI:1860755
Synonyms: Tlr4-, TLR4-KO, TLR4lps-
Gene: Tlr4  Location: Chr4:66745788-66765338 bp, + strand  Genetic Position: Chr4, 34.66 cM
Alliance: Tlr4lps-del page
Mutation
origin
Strain of Origin:  C57BL/10ScN
Mutation
description
Allele Type:    Spontaneous (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThis allele has been characterized by lack of mRNA owing to a deletion of the locus. 74723bp of genomic DNA sequence have been removed, encompassing only the Tlr4 gene. (J:51522, J:122203)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 11 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 6 strains available      Cell Lines: 0 lines available
Carrying any Tlr4 Mutation:  90 strains or lines available
Notes
C57BL/10ScN, C57BL/10ScNJ, and C57BL10/ScCr mice carry this allele.
References
Original:  J:6086 Vogel SN, et al., Characterization of a congenitally LPS-resistant, athymic mouse strain. J Immunol. 1979 Feb;122(2):619-22
All:  340 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory