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Chemically induced Allele Detail
Symbol: Tsk2
Name: tight skin 2
MGI ID: MGI:1860700
Gene: Tsk2  Location: unknown  Genetic Position: Chr1, Syntenic
Strain of Origin:  101/H
Allele Type:    Chemically induced (ENU)
Inheritance:    Semidominant
View phenotypes for all genotypes (concatenated display).
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Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tsk2 Mutation:  1 strain or line available
This mutation was found among offspring of a 101/H male treated with 200 mg/kg ethylnitrosourea (ENU), and shown to be a second tight skin mutation (see Fbn1Tsk). Homozygotes probably die prenatally (J:14073). Heterozygotes can be recognized at 1 to 2 weeks of age by tightness of the skin over the shoulders when picked up. No other abnormality was detected and the mice are fully viable and fertile. Histological examination of the skin of these mice reveals accumulation of collagen and mononuclear cell infiltration in dermis and adipose tissue. An increased collagen content is found biochemically, and steady-state levels of Col1a1 mRNA. These abnormalities resemble those of human patients with systemic sclerosis (J:31216).

Original:  J:14073 Peters J, et al., Tight skin-2 (Tsk-2). Mouse News Lett. 1986;74:91-2
All:  7 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
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