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Targeted Allele Detail
Symbol: Relatm1Yuo
Name: v-rel reticuloendotheliosis viral oncogene homolog A (avian); targeted mutation 1, Yuichi Obata
MGI ID: MGI:1860444
Synonyms: p65-, relA -
Gene: Rela  Location: Chr19:5637483-5648130 bp, + strand  Genetic Position: Chr19, 4.34 cM, cytoband B1-3
Germline Transmission:  Earliest citation of germline transmission: J:63099
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neomycin selection cassette was inserted 3 base pairs downstream of the translation initiation codon. Northern analysis of total RNA isolated from homozygous mutant embryos showed an absence of transcript. (J:63099)
Inheritance:    Recessive
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 67 assay results
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Rela Mutation:  20 strains or lines available
Original:  J:63099 Doi TS, et al., NF-kappa B RelA-deficient lymphocytes: normal development of T cells and B cells, impaired production of IgA and IgG1 and reduced proliferative responses. J Exp Med. 1997 Mar 3;185(5):953-61
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory