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Apaf1tm1Her
Targeted Allele Detail
Nomenclature
Symbol: Apaf1tm1Her
Name: apoptotic peptidase activating factor 1; targeted mutation 1, Joachim Herz
MGI ID: MGI:1860245
Synonyms: Apaf1-
Gene: Apaf1  Location: Chr10:90989311-91082770 bp, - strand  Genetic Position: Chr10, 45.47 cM, cytoband C3-D1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:60409
Parent Cell Line:  SM1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsInsertion of a neomycin casette into sequences encoding the Ced 4 homology domain corresponding to amino acid 111. Insertion disrupts the reading frame of the protein. (J:60409)
Inheritance:    Recessive
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 4 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Apaf1 Mutation:  41 strains or lines available
References
Original:  J:60409 Honarpour N, et al., Adult Apaf-1-deficient mice exhibit male infertility. Dev Biol. 2000 Feb 15;218(2):248-58
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory