About   Help   FAQ
Myo7ash1-6J
Spontaneous Allele Detail
Nomenclature
Symbol: Myo7ash1-6J
Name: myosin VIIA; shaker 1, 6 Jackson
MGI ID: MGI:1860092
Synonyms: Myo7a6J, sh6J
Gene: Myo7a  Location: Chr7:98051060-98119524 bp, - strand  Genetic Position: Chr7, 53.57 cM
Mutation
origin
Strain of Origin:  BKS.Cg-Dock7m Leprdb
Mutation
description
Allele Type:    Spontaneous
Mutation:    Single point mutation
 
Mutation detailsA G-to-C transversion mutation is predicted to result in an arginine to proline change at position 241 in the encoded protein. This mutation is predicted to lie within the head domain of the protein. Northern blot analysis indicated that mRNA expression, size, and stability were unaffected. Immunoblot analysis showed that approximately 20% of the normal level of the protein was expressed. (J:23257)
Inheritance:    Recessive
Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Disease models
Loading...
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Myo7a Mutation:  34 strains or lines available
References
Original:  J:17340 Letts VA, et al., Remutation at the shaker-1 locus. Mouse Genome. 1994;92(1):116
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/30/2015
MGI 5.22
The Jackson Laboratory