About   Help   FAQ
Tnfrsf1btm1Imx
Targeted Allele Detail
Nomenclature
Symbol: Tnfrsf1btm1Imx
Name: tumor necrosis factor receptor superfamily, member 1b; targeted mutation 1, Immunex Research and Development Corporation
MGI ID: MGI:1860087
Synonyms: p75-, p75 KO, TNFbeta ko, TNFR2-, TNFRII-, Tnfrsf1btm1Imx
Gene: Tnfrsf1b  Location: Chr4:145213463-145246870 bp, - strand  Genetic Position: Chr4, 78.17 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:45147
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA PGK-neomycin resistance cassette replaced 1kb of sequence encoding amino acids 3 - 26. Lack of gene product was shown functionally. (J:45147)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Tnfrsf1b Mutation:  21 strains or lines available
References
Original:  J:45147 Peschon JJ, et al., TNF receptor-deficient mice reveal divergent roles for p55 and p75 in several models of inflammation. J Immunol. 1998 Jan 15;160(2):943-52
All:  209 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/12/2018
MGI 6.12
The Jackson Laboratory