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Tnfrsf8tm1Mak
Targeted Allele Detail
Nomenclature
Symbol: Tnfrsf8tm1Mak
Name: tumor necrosis factor receptor superfamily, member 8; targeted mutation 1, Tak Mak
MGI ID: MGI:1860056
Synonyms: CD30 -
Gene: Tnfrsf8  Location: Chr4:145267137-145315164 bp, - strand  Genetic Position: Chr4, 78.17 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:62854
Parent Cell Line:  E14K (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA construct containing a neomycin resistance gene in the antisense direction was used to replace the second last (or second to last) exon. A dish binding assay indicated the absence of functional Tnfrsf8 protein on the surface of spleen cells isolated from homozygous mutant mice. (J:62854)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tnfrsf8 Mutation:  23 strains or lines available
References
Original:  J:62854 Amakawa R, et al., Impaired negative selection of T cells in Hodgkin's disease antigen CD30-deficient mice. Cell. 1996 Feb 23;84(4):551-62
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/08/2017
MGI 6.10
The Jackson Laboratory