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Traf5tm1Hna
Targeted Allele Detail
Nomenclature
Symbol: Traf5tm1Hna
Name: TNF receptor-associated factor 5; targeted mutation 1, Hiroyasu Nakano
MGI ID: MGI:1859960
Synonyms: traf5-
Gene: Traf5  Location: Chr1:191997205-192059162 bp, - strand  Genetic Position: Chr1, 97.11 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:57114
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 2 was replaced by the insertion of a neomycin selection cassette. The deleted region encoded the carboxy terminal half of the zinc RING finger domain. Encoded protein was undetected in homozygous mutant mice by Western blot analysis of lung tissue lysates. (J:57114)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Traf5 Mutation:  11 strains or lines available
References
Original:  J:57114 Nakano H, et al., Targeted disruption of Traf5 gene causes defects in CD40- and CD27-mediated lymphocyte activation. Proc Natl Acad Sci U S A. 1999 Aug 17;96(17):9803-8
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory