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Targeted Allele Detail
Symbol: Traf5tm1Hna
Name: TNF receptor-associated factor 5; targeted mutation 1, Hiroyasu Nakano
MGI ID: MGI:1859960
Synonyms: traf5-
Gene: Traf5  Location: Chr1:191729166-191776868 bp, - strand  Genetic Position: Chr1, 97.11 cM
Germline Transmission:  Earliest citation of germline transmission: J:57114
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 2 was replaced by the insertion of a neomycin selection cassette. The deleted region encoded the carboxy terminal half of the zinc RING finger domain. Encoded protein was undetected in homozygous mutant mice by Western blot analysis of lung tissue lysates. (J:57114)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Traf5 Mutation:  18 strains or lines available
Original:  J:57114 Nakano H, et al., Targeted disruption of Traf5 gene causes defects in CD40- and CD27-mediated lymphocyte activation. Proc Natl Acad Sci U S A. 1999 Aug 17;96(17):9803-8
All:  21 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.21
The Jackson Laboratory