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Traf6tm1Mak
Targeted Allele Detail
Nomenclature
Symbol: Traf6tm1Mak
Name: TNF receptor-associated factor 6; targeted mutation 1, Tak Mak
MGI ID: MGI:1859953
Synonyms: TRAF6-
Gene: Traf6  Location: Chr2:101678429-101701669 bp, + strand  Genetic Position: Chr2, 53.9 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:54467
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P3/J
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsThe insertion of a neomycin selection cassette disrupted the exon encoding the translation initiation codon and the first 100 residues, which constitute the amino terminal portion of the zinc RING finger domain. Western blot analysis of renal immunoprecipitates and total renal lysates showed an absence of protein in homozygous mutant mice. (J:54467)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 41 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Traf6 Mutation:  10 strains or lines available
References
Original:  J:54467 Lomaga MA, et al., TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling. Genes Dev. 1999 Apr 15;13(8):1015-24
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory