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Targeted Allele Detail
Symbol: Tulp1tm1Pjn
Name: tubby like protein 1; targeted mutation 1, Patsy M Nishina
MGI ID: MGI:1859921
Synonyms: Tulp1-
Gene: Tulp1  Location: Chr17:28351515-28365182 bp, - strand  Genetic Position: Chr17, 14.66 cM
Germline Transmission:  Earliest citation of germline transmission: J:59884
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 8 and 9 were replaced by a neomycin selection cassette. Western blot analysis revealed an absence of encoded protein in the retinas and brains and brains of homozygous mutant mice. Immunofluorescence analysis of retinal tissue confirmed the blotting analysis. (J:59884, J:79602)
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tulp1 Mutation:  6 strains or lines available
Original:  J:59884 Ikeda S, et al., Retinal degeneration but not obesity is observed in null mutants of the tubby-like protein 1 gene. Hum Mol Genet. 2000 Jan 22;9(2):155-63
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
The Jackson Laboratory