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Gnb5flr
Spontaneous Allele Detail
Nomenclature
Symbol: Gnb5flr
Name: guanine nucleotide binding protein (G protein), beta 5; flailer
MGI ID: MGI:1858521
Synonyms: flail, flr, tb2J
Gene: Gnb5  Location: Chr9:75213570-75253158 bp, + strand  Genetic Position: Chr9, 42.3 cM
Mutation
origin
Strain of Origin:  C57BL/10J x B6CBA/Ca
Mutation
description
Allele Type:    Spontaneous
Mutation:    Other
 
Mutation detailsHybrid. This mutation is caused by gene shuffling between Gnb5 and Myo5a. The shuffling combines the promoter of the first two exons of Gnb5 with the C-terminal exons of Myo5a. Flailer homozygotes express transcripts of three genes: wild-type Gnb5, wild-type Myo5a and the flailer hybrid gene. (J:61324)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Gnb5 Mutation:  17 strains or lines available
Notes
The flailer mutation, originally called tb2J, was a presumed remutation of tb because of a similar phenotype. This mutation, however, does not map to Chr 1, and the original unpublished report of linkage of tb to Chr 1 is in doubt. Thus, it is not clear whether tb2J is a remutation at the tb locus which was not on Chr 1, or if tb2J is a new mutation at a different locus. Because of its linkage to a different chromosome, tb2J was renamed flr.

flr mutants have a variable neurological phenotype. Half of all flailer homozygotes show severe ataxia and only live for 3 weeks; these mutants tend to fall over and flail their limbs in an effort to right themselves. The other half of flailer homozygotes, however, only develop a transient ataxia; they recover, are fertile, and have a normal life span.

References
Original:  J:30778 Sweet HO, et al., Remutations at The Jackson Laboratory (Update to Mouse Genome 1993; 91:862-5 - J16313). Mouse Genome. 1995;93(4):1030-4
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory