About   Help   FAQ
Brca1tm1Whl
Targeted Allele Detail
Nomenclature
Symbol: Brca1tm1Whl
Name: breast cancer 1; targeted mutation 1, Weu-Hwa Lee
MGI ID: MGI:1858107
Synonyms: Brca1 (-), Brca1ko
Gene: Brca1  Location: Chr11:101488764-101551955 bp, - strand  Genetic Position: Chr11, 65.18 cM, cytoband D
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:34458
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 184 bp fragment of the Brca1 gene corresponding to amino acids 300-361 was deleted and replaced with a neomycin cassette. (J:34458)
Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Brca1 Mutation:  39 strains or lines available
References
Original:  J:34458 Liu CY, et al., Inactivation of the mouse Brca1 gene leads to failure in the morphogenesis of the egg cylinder in early postimplantation development. Genes Dev. 1996 Jul 15;10(14):1835-43
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/17/2015
MGI 5.21
The Jackson Laboratory