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Fancctm1Mgo
Targeted Allele Detail
Nomenclature
Symbol: Fancctm1Mgo
Name: Fanconi anemia, complementation group C; targeted mutation 1, Markus Grompe
MGI ID: MGI:1858041
Synonyms: facdeltaexon 9
Gene: Fancc  Location: Chr13:63304709-63497278 bp, - strand  Genetic Position: Chr13, 32.8 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:61512
Parent Cell Line:  AK7 (ES Cell)
Strain of Origin:  129S4/SvJaeSor
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced a genomic DNA fragment containing exon 9. RT-PCR analysis demonstrated that an abnormal transcript lacking only exon 9 was produced from this allele; however, no functional protein can be expressed from this mutant transcript. (J:61512)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 24 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fancc Mutation:  38 strains or lines available
References
Original:  J:61512 Whitney MA, et al., Germ cell defects and hematopoietic hypersensitivity to gamma-interferon in mice with a targeted disruption of the Fanconi anemia C gene. Blood. 1996 Jul 1;88(1):49-58
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/24/2015
MGI 5.21
The Jackson Laboratory