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Targeted Allele Detail
Symbol: Ep300tm1Dli
Name: E1A binding protein p300; targeted mutation 1, David Livingston
MGI ID: MGI:1858020
Synonyms: p300-
Gene: Ep300  Location: Chr15:81470329-81536278 bp, + strand  Genetic Position: Chr15, 38.16 cM
Germline Transmission:  Earliest citation of germline transmission: J:47301
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA genomic fragment containing exons encoding the first cys/his rich domain were replaced with a neomycin selection cassette. Western blot analysis on embryonic fibroblasts derived from homozygous E10.5 embryos demonstrated that no detectable protein was expressed. (J:47301)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 16 assay results
In Structures Affected by this Mutation: 11 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ep300 Mutation:  64 strains or lines available
Original:  J:47301 Yao TP, et al., Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300. Cell. 1998 May 1;93(3):361-72
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory