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Pou3f4tm1Cren
Targeted Allele Detail
Nomenclature
Symbol: Pou3f4tm1Cren
Name: POU domain, class 3, transcription factor 4; targeted mutation 1, Bryan Crenshaw III
MGI ID: MGI:1857990
Synonyms: Brn4-
Gene: Pou3f4  Location: ChrX:110814280-110817207 bp, + strand  Genetic Position: ChrX, 48.2 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:56294
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA lacZ reporter gene and a PGK-neomycin resistance cassette replaced the entire intronless coding region and a small region of 3'-flanking sequences. (J:56294)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 13 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pou3f4 Mutation:  4 strains or lines available
References
Original:  J:56294 Phippard D, et al., Targeted mutagenesis of the POU-domain gene Brn4/Pou3f4 causes developmental defects in the inner ear. J Neurosci. 1999 Jul 15;19(14):5980-9
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory