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E2f1tm1Njd
Targeted Allele Detail
Nomenclature
Symbol: E2f1tm1Njd
Name: E2F transcription factor 1; targeted mutation 1, Nicholas J Dyson
MGI ID: MGI:1857944
Synonyms: E2f1-, E2F-1-
Gene: E2f1  Location: Chr2:154559407-154569892 bp, - strand  Genetic Position: Chr2, 76.79 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:33099
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAll of exon 2 and part of exon 3, encoding residues critical for cyclin and DNA binding, was replaced with a neomycin cassette in antisense orientation. Immunoprecipitation and Western blot analysis demonstrated that no protein was made in fibroblasts isolated from E12.5 homozygous embryos. (J:33099)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any E2f1 Mutation:  16 strains or lines available
References
Original:  J:33099 Yamasaki L, et al., Tumor induction and tissue atrophy in mice lacking E2F-1. Cell. 1996 May 17;85(4):537-48
All:  28 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory