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Targeted Allele Detail
Symbol: Cdkn2atm1Rdp
Name: cyclin dependent kinase inhibitor 2A; targeted mutation 1, Ronald DePinho
MGI ID: MGI:1857942
Synonyms: ARF-, Cdkn2a-, Cdkn2alox, ink4a-, INK4a-, Ink4a/arf-, Ink4a/Arf-, INK4a-Arf-, Ink4a/ArfKO, Ink4a-Arf-null, Inkdelta2/3 null, p16INK4a, p16INK4a-, p16-KO, p16p19null
Gene: Cdkn2a  Location: Chr4:89192710-89212856 bp, - strand  Genetic Position: Chr4, 42.15 cM, cytoband C3-C6
Degenerative phenotypes, including increased apoptosis in gastrointestinal crypts and germ cell depletion, in Terctm1Rdp/Terctm1Rdp and Cdkn2atm1Rdp/Cdkn2atm1Rdp Terctm1Rdp/Terctm1Rdp mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:53805
Parent Cell Line:  WW6 (ES Cell)
Strain of Origin:  STOCK 129/Sv and C57BL/6J and SJL
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons E2 and E3 were deleted and replaced by a neomycin cassette. Note that both the p16Ink4a and p19ARF alternative splice transcripts are mutated in this allele. (J:53805)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 3 assay results
In Structures Affected by this Mutation: 10 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 6 strains available      Cell Lines: 0 lines available
Carrying any Cdkn2a Mutation:  56 strains or lines available
Phenotypic Similarity to Human Syndrome in Orthologous Human Gene: human supratentorial ependymoma subgroup in homozygous mice (J:163931)
Original:  J:53805 Serrano M, et al., Role of the INK4a locus in tumor suppression and cell mortality. Cell. 1996 Apr 5;85(1):27-37
All:  298 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.19
The Jackson Laboratory