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Targeted Allele Detail
Symbol: Xpatm1Hvs
Name: xeroderma pigmentosum, complementation group A; targeted mutation 1, Harry van Steeg
MGI ID: MGI:1857939
Synonyms: XPA-, XpaKO
Gene: Xpa  Location: Chr4:46155347-46196311 bp, - strand  Genetic Position: Chr4, 24.49 cM, cytoband C2
Ercc6tm1Gvh/Ercc6tm1Gvh Xpatm1Hvs/Xpatm1Hvs mice display postnatal growth retardation

Show the 10 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:28710
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA PGK-neomycin resistance cassette replaced exons 3 and 4 of the Xpa gene. No stable intact or truncated XPA transcripts were detected in livers of homozygous mutant animals. (J:28710)
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Xpa Mutation:  8 strains or lines available
Original:  J:28710 de Vries A, et al., Increased susceptibility to ultraviolet-B and carcinogens of mice lacking the DNA excision repair gene XPA. Nature. 1995 Sep 14;377(6545):169-73
All:  63 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.01
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