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Targeted Allele Detail
Symbol: Ptentm1Mak
Name: phosphatase and tensin homolog; targeted mutation 1, Tak W Mak
MGI ID: MGI:1857937
Synonyms: mPTEN-, mPTEN3-5, Pten-
Gene: Pten  Location: Chr19:32757497-32826160 bp, + strand  Genetic Position: Chr19, 28.14 cM
Embryonic defects in Ptentm1Mak/Pten+

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:50437
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin selection cassette replaced a genomic fragment containing the splice donor site of exon 2 and exons 3-5. RT-PCR analysis on liver RNA from heterozygous mice demonstrated that an aberrant, smaller transcript was made from this allele, but no functional protein is predicted to be made. (J:50437)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pten Mutation:  50 strains or lines available
Original:  J:50437 Suzuki A, et al., High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice. Curr Biol. 1998 Oct 22;8(21):1169-78
All:  22 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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