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Pgrtm1Bwo
Targeted Allele Detail
Summary
Symbol: Pgrtm1Bwo
Name: progesterone receptor; targeted mutation 1, Bert W O'Malley
MGI ID: MGI:1857933
Synonyms: PR-, PRKO
Gene: Pgr  Location: Chr9:8899834-8968612 bp, + strand  Genetic Position: Chr9, 2.46 cM
Alliance: Pgrtm1Bwo page
Uterine defects in Pgrtm4.2Lyd/Pgrtm4.2Lyd and Pgrtm1Bwo/Pgrtm1Bwo mice

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:28980
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin cassette was inserted into the first exon and downstream from the initiating codons that encode the A and B isoforms to effectively disrupt transcription of both isoforms. Northern analysis indicated a lack of gene specific transcript. Competitive binding assays for the progesterone receptor indicated a lack a functional protein in homozygous mutant animals. (J:28980)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 3 assay results
1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 17 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Pgrtm1Bwo
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Pgr Mutation:  73 strains or lines available
References
Original:  J:28980 Lydon JP, et al., Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities. Genes Dev. 1995 Sep 15;9(18):2266-78
All:  72 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory