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Targeted Allele Detail
Symbol: Gjb1tm1Kwi
Name: gap junction protein, beta 1; targeted mutation 1, Klaus Willecke
MGI ID: MGI:1857927
Synonyms: Cx32-
Gene: Gjb1  Location: ChrX:101376378-101385629 bp, + strand  Genetic Position: ChrX, 44.06 cM, cytoband D-F4
Germline Transmission:  Earliest citation of germline transmission: J:36146
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neomycin resistance cassette was inserted into exon 2 of the gene, resulting in a stop codon 90 nucleotides after the translational start and a new start codon 15 base pairs further downstream. Northern blots of total liver RNA from homozygous mutant mice showed no detectable transcript for the gene. (J:36146)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 1 assay results
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gjb1 Mutation:  30 strains or lines available
Original:  J:36146 Nelles E, et al., Defective propagation of signals generated by sympathetic nerve stimulation in the liver of connexin32-deficient mice. Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9565-70
All:  60 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
The Jackson Laboratory