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Targeted Allele Detail
Symbol: Nkx3-2tm1.1Tlu
Name: NK3 homeobox 2; targeted mutation 1.1, Thomas Lufkin
MGI ID: MGI:1857926
Synonyms: Bapx1 -, Bapx1 neo-
Gene: Nkx3-2  Location: Chr5:41761483-41764220 bp, - strand  Genetic Position: Chr5, 22.58 cM
Germline Transmission:  Earliest citation of germline transmission: J:55583
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsReplacement of exon 1 and most of exon 2, which corresponds to nearly all of the coding region, with a lox-P flanked neomycin cassette. The neomycin cassette was removed via Cre mediated recombination in the final allele. (J:55583)
Inheritance:    Recessive
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 25 assay results
In Structures Affected by this Mutation: 18 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nkx3-2 Mutation:  15 strains or lines available
Original:  J:55583 Tribioli C, et al., The murine Bapx1 homeobox gene plays a critical role in embryonic development of the axial skeleton and spleen. Development. 1999 Dec;126(24):5699-711
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory