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Targeted Allele Detail
Symbol: Itgavtm1Hyn
Name: integrin alpha V; targeted mutation 1, Richard Hynes
MGI ID: MGI:1857889
Synonyms: alphav-null
Gene: Itgav  Location: Chr2:83554741-83637260 bp, + strand  Genetic Position: Chr2, 49.33 cM
Germline Transmission:  Earliest citation of germline transmission: J:50951
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance cassette replaced a genomic fragment containing the first exon, which encodes the signal peptide and first 30 amino acids of the mature protein. No mature protein was detected by immunoprecipitation studies on the cell surface of E16 or neonate dermal fibroblasts derived from homozygous mice. (J:50951)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 1 assay results
In Structures Affected by this Mutation: 13 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Itgav Mutation:  39 strains or lines available
Original:  J:50951 Bader BL, et al., Extensive vasculogenesis, angiogenesis, and organogenesis precede lethality in mice lacking all alpha v integrins. Cell. 1998 Nov 13;95(4):507-19
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory