Itgav^tm1Hyn
Targeted Allele Detail

Summary

• Symbol: Itgav^tm1Hyn
• Name: integrin alpha V; targeted mutation 1, Richard Hynes
• MGI ID: MGI:1857889
• Synonyms: alphav-null
• Gene: Itgav Location: Chr2:83554796-83637261 bp, + strand Genetic Position: Chr2, 49.33 cM
• Alliance: Itgav^tm1Hyn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:50951
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced a genomic fragment containing the first exon, which encodes the signal peptide and first 30 amino acids of the mature protein. No mature protein was detected by immunoprecipitation studies on the cell surface of E16 or neonate dermal fibroblasts derived from homozygous mice. (J:50951)

Expression

In Mice Carrying this Mutation:	1 assay results
In Structures Affected by this Mutation:	12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Itgav Mutation: 53 strains or lines available

References

• Original: J:50951 Bader BL, et al., Extensive vasculogenesis, angiogenesis, and organogenesis precede lethality in mice lacking all alpha v integrins. Cell. 1998 Nov 13;95(4):507-19
• All: 6 reference(s)