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Apaf1Gt(IRESBetageo)XIX18Pgr
Gene trapped Allele Detail
Nomenclature
Symbol: Apaf1Gt(IRESBetageo)XIX18Pgr
Name: apoptotic peptidase activating factor 1; gene trap XIX18, Peter Gruss
MGI ID: MGI:1857868
Synonyms: Apaf1-, Apaf1tm1Pgr
Gene: Apaf1  Location: Chr10:90989311-91082770 bp, - strand  Genetic Position: Chr10, 45.47 cM, cytoband C3-D1
Mutation
origin
Mutant Cell Line:  XIX18 (Peter Gruss)
Germline Transmission:  Earliest citation of germline transmission: J:49840
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Gene trapped
Mutation:    Insertion of gene trap vector     Vector: pSABetageo     Vector Type: gene trap
 
Mutation detailsInsertion of a gene trap vector at the 3' end of the gene downstream of the position corresponding to amino acid 1018. (J:49840)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Apaf1 Mutation:  14 strains or lines available
Notes
Phenotypic Similarity to Human Syndrome: Noonan syndrome in homozygous mice (J:49840)

References
Original:  J:40076 Chowdhury K, et al., Evidence for the stochastic integration of gene trap vectors into the mouse germline. Nucleic Acids Res. 1997 Apr 15;25(8):1531-6
All:  18 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/12/2015
MGI 5.21
The Jackson Laboratory