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Raratm2Ipc
Targeted Allele Detail
Nomenclature
Symbol: Raratm2Ipc
Name: retinoic acid receptor, alpha; targeted mutation 2, Pierre Chambon
MGI ID: MGI:1857867
Synonyms: Raralpha1, RaRalpha1-
Gene: Rara  Location: Chr11:98927818-98974942 bp, + strand  Genetic Position: Chr11, 62.76 cM, cytoband D-E1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:13574
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsInsertion of a neomycin cassette into exon 3. This disruption selectively prevents the synthesis of the alpha 1 isoform. RNAase protection analysis indicated that the mRNA encoding the alpha 1 isoform was mutated in this allele, and the alpha 2 isoform was transcribed normally. (J:13574)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 6 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rara Mutation:  66 strains or lines available
References
Original:  J:13574 Lufkin T, et al., High postnatal lethality and testis degeneration in retinoic acid receptor alpha mutant mice. Proc Natl Acad Sci U S A. 1993 Aug 1;90(15):7225-9
All:  5 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory