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Parp1tm1Zqw
Targeted Allele Detail
Nomenclature
Symbol: Parp1tm1Zqw
Name: poly (ADP-ribose) polymerase family, member 1; targeted mutation 1, Zhao-Qi Wang
MGI ID: MGI:1857862
Synonyms: ADPRT-, Adprt1tm1Wag, ARTD1-, PARP-, PARP-1-, PARS-, PKO
Gene: Parp1  Location: Chr1:180568924-180601254 bp, + strand  Genetic Position: Chr1, 84.44 cM, cytoband H5
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:23942
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA promoterless neomycin gene replaced part of exon 2 and intron 2. The neomycin sequences were fused in-frame to the coding sequence of the gene. Northern blot analysis detected a truncated fusion transcript in homozygous mice. Enzyme activity assays demonstrated a lack of functional ADPRT1 protein in homozygous mice. (J:23942)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Parp1 Mutation:  45 strains or lines available
References
Original:  J:23942 Wang ZQ, et al., Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease. Genes Dev. 1995 Mar 1;9(5):509-20
All:  94 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/18/2017
MGI 6.08
The Jackson Laboratory