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Targeted Allele Detail
Symbol: Parp1tm1Jmdm
Name: poly (ADP-ribose) polymerase family, member 1; targeted mutation 1, Josiane Menissier de Murcia
MGI ID: MGI:1857861
Synonyms: PARP-, parp-1-, Parp-1 KO
Gene: Parp1  Location: Chr1:180568975-180601254 bp, + strand  Genetic Position: Chr1, 84.44 cM, cytoband H5
Germline Transmission:  Earliest citation of germline transmission: J:41742
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neomycin resistance cassette was inserted into the fourth exon of the gene. No ADPRT1 protein was present in homozygous mice as assayed by Western blot analysis and activity blot analysis using cells isolated from spleen and testis. (J:41742)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Parp1 Mutation:  21 strains or lines available
With respect to apoptosis, the absence of ADRP drastically increased the sensitivity of primary bone marrow cells to apoptosis induced by an alkylating agent (J:54159). ADPRP deficient cell lines established from homozygous null animals show decreased topoisomerase II activity (J:54143) as well as decreased DNA polymerase activity (J:56869). NOTE: The similarities and differences between the Parp1tm1Zqw and the Parp1tm1Jmdm alleles are reviewed in (J:53842).
Original:  J:41742 de Murcia JM, et al., Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells. Proc Natl Acad Sci U S A. 1997 Jul 8;94(14):7303-7
All:  48 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
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