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Hnf1btm1Sce
Targeted Allele Detail
Nomenclature
Symbol: Hnf1btm1Sce
Name: HNF1 homeobox B; targeted mutation 1, Silvia Cereghini
MGI ID: MGI:1857856
Synonyms: Hnf1blacZ, vHnf1-, vHNF1deltaExon1-SC
Gene: Hnf1b  Location: Chr11:83850209-83905917 bp, + strand  Genetic Position: Chr11, 51.23 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:58079
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprtb-m3
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 1 was replaced by a construct containing lacZ and neo. The deleted coding sequence encodes the entire N-terminal dimerization domain and a portion of another domain showing homology to either the human POU-A subdomain or human B-domain. Western blot analysis showed an absence of encoded protein in homozygous mutant embryos. Beta-galactosidase was expressed under the control of the endogenous promoter. (J:58079)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 49 assay results
In Structures Affected by this Mutation: 13 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Hnf1b Mutation:  3 strains or lines available
References
Original:  J:58079 Barbacci E, et al., Variant hepatocyte nuclear factor 1 is required for visceral endoderm specification. Development. 1999 Nov;126(21):4795-805
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory