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Targeted Allele Detail
Symbol: Nrp1tm1Hfu
Name: neuropilin 1; targeted mutation 1, Hajime Fujisawa
MGI ID: MGI:1857853
Synonyms: NP1-
Gene: Nrp1  Location: Chr8:129085085-129229844 bp, + strand  Genetic Position: Chr8, 75.78 cM, cytoband E
Germline Transmission:  Earliest citation of germline transmission: J:44328
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin cassette replaces sequences encoding the a1 domain of the protein. The mutant allele was expected to encode only the signal peptide and the most N-terminal 7 amino acid residues of the protein. Immunohistochemical analysis of homozygous mutant embryos demonstrated the lack of intact protein. (J:44328)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 27 assay results
In Structures Affected by this Mutation: 16 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Nrp1 Mutation:  55 strains or lines available
Original:  J:44328 Kitsukawa T, et al., Neuropilin-semaphorin III/D-mediated chemorepulsive signals play a crucial role in peripheral nerve projection in mice. Neuron. 1997 Nov;19(5):995-1005
All:  29 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.21
The Jackson Laboratory