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Pax7tm1Pgr
Targeted Allele Detail
Nomenclature
Symbol: Pax7tm1Pgr
Name: paired box 7; targeted mutation 1, Peter Gruss
MGI ID: MGI:1857831
Gene: Pax7  Location: Chr4:139737062-139833528 bp, - strand  Genetic Position: Chr4, 70.83 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:32018
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin cassette was inserted into the first exon of the paired box. This targeting strategy was expected to abolish the DNA binding activity of the paired domain. (J:32018)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 8 assay results
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pax7 Mutation:  33 strains or lines available
References
Original:  J:32018 Mansouri A, et al., Dysgenesis of cephalic neural crest derivatives in Pax7-/- mutant mice. Development. 1996 Mar;122(3):831-8
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/22/2020
MGI 6.16
The Jackson Laboratory