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Pla2g2aMom1-s
Spontaneous Allele Detail
Nomenclature
Symbol: Pla2g2aMom1-s
Name: phospholipase A2, group IIA (platelets, synovial fluid); modifier of Min1, tumor susceptibility
MGI ID: MGI:1857821
Synonyms: IIA sPLA2, Mom-1, sPLA2 IIa, sPLA2-IIA-
Gene: Pla2g2a  Location: Chr4:138831857-138835186 bp, + strand  Genetic Position: Chr4, 70.57 cM
Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Spontaneous
Mutation:    Insertion
 
Mutation detailsInsertion of thymidine at position 208 (position 166 from the ATG) results in a frameshift that creates a stop codon 13 amino acids downstream in exon 4. The mutation causes the loss of a BamHI restriction site and a defective protein. (J:26137, J:28799)
Inheritance:    Dominant
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pla2g2a Mutation:  7 strains or lines available
Notes
129 substrains, C57BL/6J and BTBR carry this inbred strain variant allele.

A mutation in the Apc gene of the mouse causes multiple intestinal adenomas in the C57BL/6J strain on which it arose. In crosses with other strains, the number of tumors is reduced. A locus controlling about 50% of genetic variation in tumor number has been identified as Pla2g2a.

References
Original:  J:15703 Dietrich WF, et al., Genetic identification of Mom-1, a major modifier locus affecting Min-induced intestinal neoplasia in the mouse. Cell. 1993 Nov 19;75(4):631-9
All:  31 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/15/2020
MGI 6.15
The Jackson Laboratory