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Targeted Allele Detail
Symbol: Acox1tm1Jkr
Name: acyl-Coenzyme A oxidase 1, palmitoyl; targeted mutation 1, Janardan K Reddy
MGI ID: MGI:1857811
Synonyms: ACOX-, Acox1-, AOX-
Gene: Acox1  Location: Chr11:116171888-116199045 bp, - strand  Genetic Position: Chr11, 80.96 cM
Hepatocellular alterations in liver of Acox1tm1Jkr/Acox1tm1Jkr mice

Show the 7 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:35794
Parent Cell Line:  BK4 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 1.3kb SstI-BamHI segment containing exons 8 and 9 was replaced with a neomycin selection cassette. The 3.8-kb transcript is undetectable in RNA derived from the livers of homozygous mice by Northern blot. Western blots and enzymatic assays confirmed the absence of functional protein in homozygous mice. (J:35794)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Acox1 Mutation:  25 strains or lines available
Original:  J:35794 Fan CY, et al., Hepatocellular and hepatic peroxisomal alterations in mice with a disrupted peroxisomal fatty acyl-coenzyme A oxidase gene. J Biol Chem. 1996 Oct 4;271(40):24698-710
All:  18 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
The Jackson Laboratory