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Targeted Allele Detail
Symbol: Adcy1tm1Drs
Name: adenylate cyclase 1; targeted mutation 1, Daniel R Storm
MGI ID: MGI:1857775
Synonyms: AC1-, I-AC-
Gene: Adcy1  Location: Chr11:7063489-7178506 bp, + strand  Genetic Position: Chr11, 4.72 cM, cytoband A2
Germline Transmission:  Earliest citation of germline transmission: J:22287
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin selection casssette replaced a genomic fragment including part of exon 1. Northern blot analysis demonstrated that the transcript was not detectable in RNA from homozygous mice. (J:22287)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 12 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Adcy1 Mutation:  7 strains or lines available
Original:  J:22287 Wu ZL, et al., Altered behavior and long-term potentiation in type I adenylyl cyclase mutant mice. Proc Natl Acad Sci U S A. 1995 Jan 3;92(1):220-4
All:  50 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory