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Targeted Allele Detail
Symbol: Chuktm1Mka
Name: conserved helix-loop-helix ubiquitous kinase; targeted mutation 1, Michael Karin
MGI ID: MGI:1857768
Synonyms: Ikka-, Ikkalpha-
Gene: Chuk  Location: Chr19:44073335-44107480 bp, - strand  Genetic Position: Chr19, 36.71 cM
Germline Transmission:  Earliest citation of germline transmission: J:54316
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA LacZ gene and neomycin cassette replaced part of the exon that encodes the ATP binding site (amino acids 192-212). Western blot analysis on extracts of E18 embryos did not detect expression of protein expressed from this allele in homozygous mice. (J:54316)
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Chuk Mutation:  8 strains or lines available
Original:  J:54316 Hu Y, et al., Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase [see comments]. Science. 1999 Apr 9;284(5412):316-20
All:  17 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
The Jackson Laboratory